Liver Histopathology in Fish

The detection of liver neoplasms is established as a top level indicator of exposure to anthropogenic contaminants. This is particularly relevant to the assessment of macroscopic and microscopic neoplastic lesions in flatfish (dab- Limanda limanda and flounder- Platichthys flesus), although other species are also implicated.

Histopathology is used to investigate the presence of several lesion categories including: non-specific and inflammatory lesions; early non-neoplastic toxicologic lesions; foci of cellular alteration (FCA); benign and malignant neoplasms. The BEQUALM liver histopathology intercalibration primarily focuses on the diagnosis of FCAs, benign neoplasms and malignant neoplasms. Digital Pathology is used to create Whole Slide Images (WSIs) that are uploaded to the Cefas Digital Pathology Portal where participants are able to interrogate and diagnosis digital slides / case studies.

Forthcoming Intercalibrations

There are no intercalibrations confirmed for this period, although plans are currently being prepared. Please check back for more information.